Nocturia was defined as a condition in which the patient wakes up to urinate at least once per night. The present study enrolled patients with nocturia who had not previously used compression stockings. Signed informed consent was obtained from all patients before the initiation of treatment. All procedures were conducted following the Declaration of Helsinki (UMIN000047192) and with the approval of the Institutional Review Board of Dokkyo Medical University (approval number: R-42-15J). The present study aimed to investigate and supplement evidence on the effects of wearing compression stockings in the daytime on nocturia.Ī single-arm prospective analysis of the effects of compression stockings on nocturia for four weeks was performed. However, a reading of the cited literature for evidence shows that there is not enough research data to support this recommendation, and it is controversial. The compression stockings may be safe and effective for the treatment of nocturia, especially for nocturnal polyuria, when they wear in the daytime, decreasing the extra fluid accumulation in the extremities. They have been recommended for the treatment of nocturia, particularly nocturnal because they attenuate edema and decrease the accumulation of extracellular fluid in the lower extremities. Compression stockings have been widely used as a tool in compression therapies for deep vein thrombosis, varix, lymphedema, and orthostatic hypotension. Among these behavioral therapies, wearing compression stockings has been proposed as a treatment option, in addition to lifestyle interventions such as limiting night-time drinking and avoiding caffeine and alcohol. These therapies have been recommended as the first-line conservative treatment for lower urinary tract symptoms because they are non-invasive and cost-effective. Behavioral therapies include lifestyle interventions and scheduled voiding regimens, including bladder training and pelvic floor muscle training. It has been associated with falls, fractures, and mortality. Nocturnal polyuria is caused by several factors, including congestive heart failure, diabetes mellitus, obstructive sleep apnea, peripheral edema, anxiety disorders, and urologic disease. Nocturia is a complex condition that is characterized by nocturnal polyuria, decreased bladder storage function, and sleep disturbance. Based on the results of this study, we believe that it is worth considering as a treatment for nocturia. Significant reductions were also observed in all overactive bladder symptom score subscores, except for the daytime frequency score.Ĭonclusion: The present results suggest the effectiveness of wearing compression stockings during the day was satisfactory in most patients with nocturia, and the treatment was safely continued in patients who experienced no pain when wearing the stockings. The total overactive bladder symptom score significantly decreased (P = 0.006). No significant differences were observed in nocturnal or 24-h urine volumes, the number of urgency or urinary incontinence episodes, the mean or maximum voided volume, the nocturnal polyuria index, or the first night-time voided volume. The hours of undisturbed sleep significantly increased by 0.8 h (P = 0.013). In the frequency-volume chart, night-time and 24-hour frequencies significantly decreased by 0.5 and 1.1 episodes, respectively (P = 0.004 and P = 0.035, respectively). Two patients dropped out because of pain associated with wearing compression stockings and one due to a refusal to wear compression stockings every day. Results: Thirty-four patients (19 men and 15 women age: 72.3 ± 12.6 years) were included. The primary endpoint was a change in night-time frequency in the frequency-volume chart from the baseline to the end of treatment. Patients were asked to record a frequency-volume chart and complete various questionnaires at baseline and after four weeks, and also provide feedback on treatment satisfaction. Methods: This was a single-arm prospective study to investigate the effects of compression stockings on nocturia for four weeks. The present study aimed to investigate and supplement evidence on the effects of wearing compression stockings during the daytime in patients with nocturia. Objectives: Behavioral treatment for nocturia includes wearing compression stockings.
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